| 초록 |
A study on water-soluble derivatives that improve the solubility of various poorly soluble drugs including paclitaxel, the best anticancer drug, is very effective through polymer-modification. It is very important for intravenous drug administration. Therefore, this study aims to investigate the interaction between modified drug and protein. We have investigated the interaction of polymer-drug conjugate (7-mPEG5,000-succinyloxymethyloxycarbonyl-paclitaxel) and albumin by pulse-gradient field NMR. Diffusion coefficient was measured as a function of polymer-drug conjugate and albumin concentration at different temperatures. The conformation and flexibility of the polymer chains have an important effect on the transport properties of the polymer-drug conjugates in aqueous solution. |
