| 학회 | 한국화학공학회 |
| 학술대회 | 2004년 봄 (04/23 ~ 04/24, 공주대학교) |
| 권호 | 10권 1호, p.434 |
| 발표분야 | 생물화공 |
| 제목 | Production of E6 oncoprotein in recombinant Escherichia coli and its porous protein chip |
| 초록 | In most high-risk human papillomaviruses (HPVs) infection, E6 oncogenic protein plays a critical role in inducing cervical cancers by interacting with p53 for inactivation of the cellular regulatory proteins [1]. E6 protein acts by stimulating degradation of P53 through the ubiquitin-dependent proteolysis pathway. The viral E6 protein is also required for the continuous growth of HPV-immortalized cells. In this study, we constructed a recombinant E. coli and produced E6 oncoprotein to investigate the molecular pathway of tumor suppression effect with a porous protein chip [2]. [This work was supported in part by the Korea Science and Engineering Foundation (KOSEF) through the ADvanced Environment Monitoring Research Center at Kwangju Institute of Science and Technology.] REFERENCES [1] Kaur P, et al. J Gen Virol 1989;70:1261-1266. [2] Oh BK, et al. Biosens Bioelectr 2003;18:605-611 |
| 저자 | 이우창, 김용완, 천범석, 이두봉, 김희주, 최정우 |
| 소속 | 서강대 |
| 키워드 | E6 oncogenic protein; tumor suppression; protein chip |
| 원문파일 | 초록 보기 |
