| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Photosensitizer conjugated Gold nanoparticle for targeted cancer imaging and dual PDT/PTT therapy |
| 초록 |
A multifunctional theranostic platform based on photosensitizer conjugated gold nanoparticle is developed for specific cancer cell targeting, imaging and dual therapy. The nano-size gold nanoparticle (AuNP) (~20 nm) has been investigated as a promising carrier in drug delivery. Additionally it has a photothermal therapy (PTT) effect in specific wavelength laser manner. Pheophorbide-A (PhA) is a second generation photodynamic therapy (PDT) agent, provides optical properties for diagnosis. Hyaluronic acid (HA) is a biocompatible material use for targeting CD44 receptor of liver cancer cell. HA conjugated PhA can immobilized AuNP surface by gold-thiol interaction between gold and thiolated HA. In this study we indicate in vitro cell uptake and cancer cell treatment, demonstrating singlet oxygen generation and thermal therapy effect in specific laser wavelength. Therefore our HA-PhA/AuNP complex shows optical imaging and synergistic PDT/PTT treatments in targeting cancer cell effectively. |
| 저자 |
강성훈1, Md.Nafiujjaman1, 이용규1, 허강무2
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| 소속 |
1한국교통대, 2충남대 |
| 키워드 |
Gold nanoparticle; Pheophorbide-A; PDT; PTT; Dual therapy
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| E-Mail |
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