| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
Korea-Japan Joint Symposium: Fundamental Polymer Science for Future Technology (영어발표) |
| 제목 |
Physicochemical Characterization of Deep Eutectic Solvents-in-Oil Microemulsions |
| 초록 |
Deep eutectic solvents (DES) hold great promise as solvents for pharmaceutical applications because of cheap, nontoxic, biocompatible, and high solubility to various compounds, including some sparingly soluble drugs. DES-in-oil microemulsions (MEs) could be used for a transdermal delivery carrier of sparingly soluble drugs. In this study, we investigated the effect of the ratios of surfactants (Tween-80 and Span-20) and solvents in the inner phase (DES/water) on the ME structure by the analysis of small-angle X-ray scattering profiles with core-corona model. Tween-80 with an unsaturated long alkyl chain induced a structural transition of MEs from a sphere to a cylinder. DES caused the aggregation of surfactants due to the solvophobic interactions between DES and the alkyl chains of surfactants. Subsequently, we examined the structural change of the lipid layer in the stratum corneum on applying DES-in-oil ME to the stratum corneum, and their skin permeation efficiencies in vitro. |
| 저자 |
Mina Sakuragi, Shinsuke Tsutsumi, Katsuki Kusakabe
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| 소속 |
Sojo Univ. |
| 키워드 |
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| E-Mail |
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