| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.405 |
| 발표분야 |
생물화공 |
| 제목 |
Genome-scale Reconstruction of the Metabolic Network in Zymomonas mobilis ZM4 for Ethanol and Succinic acid Overproduction |
| 초록 |
Zymomonas mobilis ZM4 is famous Gram-negative bacterium that can efficiently produce ethanol from glucose, fructose, and sucrose by utilizing the Entner-Doudoroff pathway. The genome-scale metabolic model of Z. mobilis is reconstructed based on its annotated genes, literature, physiological and biochemical information to analyze the metabolic characteristics of this bacterium.The features of Z. mobilis were examined using constraints-based flux analysis. First, the physiological changes of Z. mobilis as it shifts from anaerobic to aerobic environments were investigated. Then the intensities of flux-sum, which is the cluster of either all ingoing or outgoing fluxes through a metabolite, and the maximum in silico yields of ethanol for Z. mobilis and Escherichia coli were compared and analyzed. [This work was supported by the Korean Systems Biology Research Project (20100002164) of the Ministry of Education, Science and Technology (MEST). Further support by the World Class University Program (R32-2008-000-10142-0) through the National Research Foundation of Korea funded by the MEST is appreciated.] |
| 저자 |
김진년, 이경윤, 박종명, 김태용, 윤홍석, 이상엽
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| 소속 |
카이스트 |
| 키워드 |
Genome-scale Metabolic Network; flux balance analysis; Zymomonas mobilis
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| E-Mail |
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| 원문파일 |
초록 보기 |
