| 초록 |
Cell-based immunotherapies typically depend on ex vivo culture of a patient’s cells, and/or biomaterials that must be surgically implanted to program host immune cells. Here, we propose that mesoporous silica microrods can be injected into the body, and spontaneously assembled to form 3D cellular microenvironment for host immune cells. Substantial numbers of DCs are recruited to the interparticle macropores of the injected scaffold. The DC recruitment and subsequent homing to lymph nodes can be modulated by sustained release of inflammatory signals and adjuvants, respectively. Moreover, injection of vaccine formulation enhances antigen-specific antibody and cytotoxic T cell levels. This suggests this injectable vaccine platform could be used to modulate host immune cells and provoke adaptive immune responses and more broadly demonstrate their potential utility for cell therapies. |
