| 초록 |
The approach of gene delivery with microneedle has been got many attentions in diverse studies. Although the outstanding capability of carrying DNA into body with microneedle, there is a problem on stability of DNA coated on microneedle surface when it is stored during plenty of times in room temperature. And the period of generating immune responses is important portion to verify efficiency vaccine system with microneedle. In this study, we developed the novel polypelxes delivery system based on microneedle which was accompanied with polypelxes and FMLP peptides. We could be sure that the polplexes were delivered stably and FMLP peptide was able to increase immune responses due to the ability of immune cell recruitment. Also, the microneedle injection showed more excellent induction of antigen and antibody expression than subcutaneous injection. |
