| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Characterization of antibody conjugated chitosan based nanoparticles |
| 초록 |
Chitosan is a positive charged biocompatible, non-cytotoxic, and biodegradable natural polymer. The positive charge of chitosan can form aggregation by ionic gelation with negative charged materials for chitosan based nanoparticles. Chitosan based nanoparticles are encapsulated antibody, gene, drug, and various small molecule for disease therapy. In this study, chitosan nanoparticles (Chi NPs) were prepared with tripolyphosphate (TPP), antibody (Ab) and PEG-COOH. The size and zeta-potential of Chi-Ab NPs were confirmed as under 250nm and upon +20 mV, respectively. The shape and aggregation of Chi-Ab NPs were determined by TEM. The cell viability and cellular uptake were confirmed in MRC-5 lung fibroblast cells. In conclusion, Chi-Ab NPs can be expected to application for various disease target antibody carrier. |
| 저자 |
이은선1, 박상준1, 조휘문1, 이보미1, 진용재1, 김용희2, 김천호1
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| 소속 |
1한국원자력의학원, 2한양대 |
| 키워드 |
polymer; nanoparticle; DDS
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| E-Mail |
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