| 초록 |
Known as an effective carrier for the delivery of the cargo, the polymer nanoparticle has been used for years. By immobilizing the polymer nanoparticles on the surface of medical materials, one may be able to fabricate the controlled cargo-releasing system for various medical devices. Herein, we suggest a titanium (Ti)-adhesive nanoparticle as a surface-releasing system for dual osteogenic growth factors. The key element that enables the nanoparticle immobilization is surface-exposed catechol groups, reported as a strong adhesive moiety for Ti or Ti oxide surfaces. We confirmed the conjugation of the catechol groups to the surface of the nanoparticle by 1H NMR and UV-Vis spectra. The immobilization of the nanoparticles onto the surface of Ti substrates was confirmed by various analytical tools, such as Fe-SEM and XPS. The release of dual proteins lasted for up to 28 days, and we carried out various cell experiments to verify the effects of our surface-releasing system. |
