| 초록 |
Chitosan derivatives, 6-amino-6-deoxychitosan (6A6DC) was successively prepared as a reactive carbohydrate for the stabilization of epidermal growth factor(EGF) by the reactions of chitosan with tosyl chloride, sodium azide, and LiAlH4. The structure of 6A6DC was confirmed by FT-IR spectra. 6A6DC did not show any cytotoxicity on the normal human dermal fibroblast(NHDF) proliferation. Therefore 6A6DC was considered as a suitable material for the stabilization of EGF against proteolytic degradation due to its non-cytotoxicity and high reactivity. |
