| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
International Symposium on Theranostic Macromolecules(의료용 고분자 부문위원회) |
| 제목 |
Bio-Inspired Self-Assembly of Peptide Dendrimers into Capsid-Like Nanostructure for Drug and Gene Delivery |
| 초록 |
Supramolecular self-assembly of dendrimers is a promising approach to engineer advanced vectors for therapeutic agent delivery. Peptide dendrimers coupled with linear peptides spontaneously assembled into well-defined capsid-like nanstructure in water, whose size and morphology were controllable. The capsid-like nanstructure could serve as a pH-responsive nanovector for anticancer drug delivery due to inherent features of peptide-based materials.The smart nanovector significantly enhanced antitumor efficacy of hydrophobic doxorubicin against HepG2 human hepatocyte tumor cell line and 4T1 murine breast tumor model. More importantly, a family of capsid-like nanovectors were used to develop towards artificial virus for gene delivery. These artificial viruses achieved high gene transfection efficiency both in vitro and in vivo gene delivery.As our continuous interest in self-assembly of peptide dendrimers, we are developing more strategies for constructing novel supramoleculardendrimers to satisfy various biomedical applications, such as multi-drug delivery, drug/gene co-delivery and theragnosticagent delivery. |
| 저자 |
ZhongweiGu1, XianghuiXu2
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| 소속 |
1National Engineering Research Center for Biomaterials, 2Sichuan Univ. |
| 키워드 |
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| E-Mail |
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