| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Release profile of nifedipine by membrane porosity and various excipients in multi-coated granules |
| 초록 |
Such oral drug delivery systems are based on osmosis. Water in medium is diffused throughout the bead, because of osmotic pressure. To improve release profile of nifedipine(ND) bead, water absorption force is important. So, we prepared for ND beads by fluidized bed coating. Osmotic agent, KCl, was added to the inside of bead to improve water absorption force. So, release rate was increased because of increased osmotic pressure. Also, aging tests were examined for storage. The problem occurred during aging test by plasticizer and was solved by remove plasticizers of liquid type. Finally, the optimal release profile was obtained by bead size, membrane thickness and several excipients. Acknowledgement : This research was supported by KMOCIE(10016482). |
| 저자 |
조영호1, 정성찬2, 이수영2, 김문석1, 강길선3, 이해방1
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| 소속 |
1한국화학(연), 2부경대, 3전북대 |
| 키워드 |
Osmotic agent; porosity; excipient
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| E-Mail |
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