| 초록 |
Controlling crystallization of pharmaceutical materials is of great importance because different size, morphology, and polymorphs can result in different physicochemical properties. Especially, solubility change is relevant to the bioavailability in pharmaceutics. We have attempted regulation of the crystallization process, especially nucleation, by employing various substrates. Substrates in our study include 1) some commercially available surfaces such as, glass, polyethylene terephthalate, polyethylene, and polytetrafluoroethylene as well as 2) self-assembled monolayers of different functional groups, such as -COOH, -NH2, and -OH, prepared on gold surfaces. Here, we report the effects of such surfaces on the crystallization of simple pharmaceutical materials including D,L-alpha lipoic acid, an effective antioxidant. |
