| 초록 |
Biodegradable materials composed with acidic monomers, generally, make human body an acidic environment, as PLLA, PCL and PGA were degraded with lactic acid, caproic acid and glycolic acid during time collapsing. This acidic environment may induce inflammation after a biodegradable stent implantation in blood vessel. To solve these problems, Mg-O-PLLA nanocomposites were prepared by ROP of L-lactide with different loading ratios of Mg(OH)2 serving as neutralizing agents. The structure, morphology, pH-change, thermal and mechanical properties of the obtained nanocomposites were analyzed by FT-IR, SEM, pH-meters, TGA, and UTM, respectively. The result showed that acidic pH was neutralized by nanocomposite containing Mg-O-PLLA particles. It was found that tensile strength of the nanocomposite films is higher than it of films made from PLLA matrix. Consequently, the nanocomposites in PLLA matrix may suppress inflammation and enhance mechanical properties for biodegradable polymeric stents |
