| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
β-Cyclodextrin conjugated thermosensitive block copolymers of poly(ethylene oxide)-block-poly(N-isopropylacrylamide-co-glycidyl methacrylate) for drug delivery |
| 초록 |
A novel drug carrier system based on β-cyclodextrin functionalized block copolymers were synthesis. Thermosensitive block copolymers of poly(ethylene oxide)-block-poly(N-isopropylacrylamide-co-glycidyl methacrylate) (PEO-b-P(NIPAm-co-GMA)) were synthesized by reversible addition fragmentation chain transfer polymerization using a PEO macro-initiator. β-Cyclodextrin was simply attached to thermosensitive block copolymers by epoxide ring-opening reaction, which were then modified inclusion-complex formation of cyclodextrin with prednisolone acetate drug. The drug loading efficiency increased in the β-cyclodextrin conjugated polymer compared to native β-cyclodextrin. The thermo-responsive micelles enhanced cytotoxicity against human breast cancer cells in vitro. |
| 저자 |
김용한, 임권택, Xuan Thang Cao, 김동우
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| 소속 |
부경대 |
| 키워드 |
Thermosensitive; Poly(N-isopropylacrylamide); β-Cyclodextrin; Inclusion-complex
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| E-Mail |
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