| 초록 |
Recently lot of Superparamagnetic Iron Oxide Nanoparticles(SPIONs) has been prepared for diagnostic enhancement studies. But the successful in vivo application for diagnosis has been hindered due to various problems which physical(size, shape), chemical(surface properties), and biological(targeting efficiency). This work has been designed to overcome the drawbacks for SPIONs in vivo diagnostic applications. In this study, SPIONs were coated with dopamine which provides amine functionality, making the situation amicable for further functionalization or conjugation with polymers or targeting agents. Hyaluronic acid coated SPIONs(HA-SPIONs) was prepared to target CD44 expressed cancer and the carrier was conjugated to PEG for longer circulation in blood and also for the biocompatibility(PEG-HA-SPIONs, HA-SPIONs-PEG). In conclusion, HA-SPIONs were targeted specifically to the CD44, MR signal drop of PEGylated HA-SPIONs was better than HA-SPIONs and PEG-SPION in vivo. |
