| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Three-dimensional double-layered hydrogel based stem cell co-culture system for enhanced cardiovascular tissue regeneration |
| 초록 |
Stem cell-based co-culture model in 3D scaffold is a promising technology for tissue regeneration. However, the cell-laden efficiency and the immune reaction effect remains as a challenge. We fabricated the multiscale alginate coated fibrin hydrogel incorporating polycaprolactone fibers can enhance the vascular tissue formation with co-culture system and reduce immune reaction by the double-layer system. Triple co-culture of ADSCs, endothelial cells, and C2C12 for cardiovascular tissue regeneration demonstrated that new blood vessel formation and cardiomyogenic differentiation of ADSCs were promoted. Further, the co-culture of ADSCs and endothelial cells without C2C12 in the multiscale hydrogel system also enhanced the angiogenesis efficiency which has the potency to be used in other vascular tissue regeneration. We expect the co-culture multiscale hydrogel system can be applied to the remodeling of several vascular tissues as well as cardiovascular tissue. |
| 저자 |
최연정1, 국윤민2, 김영환3, 임광범3, 방석호3, 이강원1
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| 소속 |
1서울대, 2한국과학기술(연), 3성균관대 |
| 키워드 |
3D scaffold; vascular tissue regeneration; hydrogel; co-culture
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| E-Mail |
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