| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Genetically engineered phage as versatile nanoink for 3D bioprinting |
| 초록 |
Bioprinting is a promising technology for producing tissue-mimetic 3-D structures using cell-containing hydrogels. Choosing the right cell-containing “bioink” material is the most essential step for fabricating 3-D constructs with a controlled mechanical and biochemical microenvironment that can lead to successful tissue regeneration. Here, we demonstrate that the genetically engineered M13 phage holds great potential for use as a versatile nanoink for printing 3-D cell-containing matrices. In particular, M13 phages displaying integrin-binding (GRGDS) and calcium-binding (DDYD) domains on their surface were blended with alginate to form Ca2+-crosslinked hydrogels. The MC3T3-E1 cells within these scaffolds showed enhanced proliferation and differentiation rates that increased proportionally with the concentration of phages in the 3-D matrices compared with the rates of cells in pure alginate scaffolds. |
| 저자 |
이상민, 이도영, 정우재
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| 소속 |
성균관대 |
| 키워드 |
Bioprinting; M13 bacteriophage; 3D scaffold; Tissue engineering
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| E-Mail |
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