| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
EGF-functionalized Gold-melanin Nanoparticles for Hyperthermia Treatment |
| 초록 |
We introduce gold and melanin (Au-melanin) hybrid nanoparticles as photothermal agents for thermal ablation of lung cancer cells. To guide these nanoparticles to cancer cells, the Au-melanin nanoparticles were functionalized with epidermal growth factors conjugated with epidermal growth factor (EGF-PEG). These EGF-PEG@Au-melanin nanoparticles exhibited high biocompatibility, efficient cellular internalization, and excellent serum dispersion stability. A549 cells were treated with the EGF-PEG@Au-melanin nanoparticles, followed by irradiated with an 808 nm laser to produce photothermal reactions. The nanoparticles specifically destroyed A549 cells after illumination under near-infrared light (NIR), but did not harm different cell lines. Acknowledgements: the Basic Science Research Program (NRF-2013R1A1A1009626). |
| 저자 |
Ghasidit Pornnoppadol1, 남윤성2
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| 소속 |
1KAIST, 2KAIST / KI for Nanocentury and Health Science and Technology |
| 키워드 |
Photothermal Therapy; Gold Nanoparticles; Melanin; Epidermal Growth Factors; A549
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| E-Mail |
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