| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The enhanced dissolution behavior of Pranlukast by Nano-Solid Dispersion with Poly(N-vinylpyrrolidone) |
| 초록 |
To enhance solubility of poorly water soluble drugs, solid dispersions containing nanoparticles of water insoluble pranlukast was prepared by using spray dryer.These solid dispersions formulated to improve the dissolution of pranlukast. PVP-K30 used as a water soluble carrier for the solid dispersion and poloxamer used as a surfactant. Characterization of pranlukast solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and particle size analyzer. SEM and DSC were found that pranlukast is amorphous in solid dispersions.Particle size analyzer was used to investigate size of pranlukast in solid dispersions. The in vitro dissolution rate of pranlukast solid dispersion was significantly higher than the conventional drugs(Onon® and Prakanon®), as 11~33 folds. This studies illustrated the potential use of solid dispersion for the delivery of poorly water soluble drug, such as pranlukast by the oral route. |
| 저자 |
성경열, 김세호, 엄신, 김용기, 조은혜, 박현진, 박종학, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Pranlukast; nano-solid dispersion; dissolution; PVP-K30; particle size
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| E-Mail |
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