| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Characterization and Release Behavior of Zaltoprofen Tablet withHPMC and CMC |
| 초록 |
Zaltoprofen is a propionic acid derivative of non-steroidal anti-inflammatory drugs (NSAIDs) and has been widely used in the treatment of a number of arthritic conditions. Zaltoprofen has low water solubility and low bioavailability, therefore great efforts have been devoted to enhance the extent of drug adsorption. In this study, zaltoprofen was formulated into a tablet to enhance the bioavailability and achieve sustained-release using additives such as carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC). FT-IR (Fourier transfer-infrared) and differential scanning calorimeter (DSC) were employed to study the structure and crystallization of zaltoprofen in the tablet with various contents of additives. Additives had interactions with zaltoprofen and inhibited the crystallization of zaltoprofen. Tablets containing low viscosity HPMC showed a higher release than those containing high viscosity HPMC. As the amount of CMC increased zaltoprofen release increased. |
| 저자 |
박현진, 홍동현, 김수진, 김수진, 성경열, 송이슬, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Zaltoprofen; Dissolution rate; Bioavailability; HPMC; CMC
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| E-Mail |
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