| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Poly (L-lactide-co-ε-caprolactone)(PLCL) coating for drug releasing medical devices |
| 초록 |
Recently, many drug releasing medical devices (drug eluting stent, antibiotics releasing catheter, etc) are used increasingly in clinical area. We have studied the in vitro release kinetics of indomethacin from drug-loaded poly (L-lactide-co-ε-caprolactone)(PLCL) and poly (ethylene vinyl acetate)(PEVA). 316L stainless steel sticks (20mm) were coated by each coating solution. The coating quality was assessed by scanning electromicroscopy analysis (SEM), release of indomethacin was characterized in vitro incubating and UV spectrophotometry. The coating was examined both pre- and post-release and did not show abnormal modifications. Release kinetics of indomethacin depended on polymer and drug concentration. Drug-loaded PLCL polymer showed slower drug release rate than drug-loaded PEVA polymer. With biodegradable property, PLCL is expected to be good coating material for drug releasing medical devices. |
| 저자 |
신영민, 임광석, 정성인, 김소연, 이영무, 김경수
|
| 소속 |
한양대 |
| 키워드 |
PLCL; PEVA; Indomethacin; Release kinetics; Medical device
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| E-Mail |
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