| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
콜로이드·계면화학_포스터 |
| 제목 |
Highly stable attractive nanoemulsions: Engineering interface, drop-to- drop interaction, and transdermal delivery |
| 초록 |
This study introduce a structurally stable attractive nanoscale emulsion fluid, in which the poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO-b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface. Our suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops. We have figured out that this unique rheological behavior is attributed to the dipolar interaction between the phosphorylcholine groups of lecithin and the methoxy end groups of PEO-b-PCL. Finally, we demonstrate that our nanoemulsion system significantly enhances transdermal delivery efficiency due to its favorable attraction to the skin as well as high diffusivity of the nanoscale emulsion drops. |
| 저자 |
신경희, 김진웅, 공경현, 이영복
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| 소속 |
한양대 |
| 키워드 |
attractive emulsion; amphiphilic block copolymer; lecithin; transdermal delivery
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| E-Mail |
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