| 초록 |
Silica/polyrhodanine core/shell nanoparticles were synthesized by chemical oxidation polymerization using Fe(III) ions as the initiator. To control the size of core/shell nanoparticles, colloidal silica nanoparticles with different diameter were used as a core material. The average diameter of the nanoparticles increased from 12, 22 and 50 nm in the pristine silica nanoparticles, to ~ 15, 27 and 56 nm after polymerization. Polyrhodanine-coated silica nanoparticles showed excellent antibacterial properties by killing both Gram-negative bacteria (Escherichia Coli) and Gram-positive human pathogens (Staphylococcus aureus). The direct-contact of the silica/polyrhodanine nanoparticles and the bacterial membrane lead to antimicrobial effects. The quantitative bactericidal efficacy increases with decreasing the size of silica/polyrhodanine nanoparticles due to the enlarged contact surface area. |
