| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity |
| 초록 |
The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). The polymeric support composed of thermo sensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68-BPEI-NONOates releases a sufficient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. It also demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68-BPEI-NONOates against resistant strains such as MRSA provides simple but highly efficient strategy to combat drug-resistant bacterial infections |
| 저자 |
박정홍, 김지훈, kaushik Singha, 김원종
|
| 소속 |
포항공과대 |
| 키워드 |
Nitric oxide; antibacterial activity; NONOates
|
| E-Mail |
|
