| 초록 |
Light-responsive drug carriers have attracted great attention because of their spatiotemporal release of drugs into desired target sites. In this study, biocompatible phage change material (PCM) and PLGA [poly(lactic-co-glycolic acid)] were used to fabricate thermo- and light-responsive drug carriers encapsulating indocyanine green (ICG) and anticancer drugs. ICG-loaded drug carriers exhibited photothermal effect under near-infrared irradiation, leading to melting of PCM and consequently facilitated drug release through temperature-triggered phase change of PCM. Tailored drug release profile was also achieved by modulating the component ratios of PCM and PLGA. This study demonstrates that ICG-loaded, PCM-based drug carriers are promising candidates for light-responsive drug delivery with a precise control over drug release and high biocompatibility. |
