| 초록 |
Hyaluronic acid (Hya) plays a vital role in many tissues, influencing water content and mechanical function, and has been shown to have positive biological effects on cell behavior in vitro. Composite nanofibers consisting of hydroxyapatyite and titania (HA/TiO2) were fabricated via electrospinning and, subsequently, hyaluronic acid (Hya) and collagen type І were co-immobilized on the surface of the nanofibers (HA/TiO2–Hya/Col) to improve biocompatibility. The composite scaffolds were compared and analyzed by SEM, XRD, XPS, and FTIR techniques. The potential for use of the composite nanofibers as bone scaffolds was assessed by using osteoblastic cell (MC3T3-E1) in terms of attachment, proliferation and differentiation. |
