| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
In Vivo Osteogenic Differentiation using BMP-2 and Factors in MPEG-PCL hydrogel |
| 초록 |
In tissue engineering, the use of injectable in situ-forming hydrogels appears to be a promising approach. In situ-forming hydrogels can incorporate various biological agents, such as growth factors and cells, simply by mixing. Aqueous solutions of MPEG-PCL exhibited sol-to-gel transitions at body temperature. Stem cell therapy draws attention as a promising treatment option for many human diseases. Adult stem cells (ASCs) are self-renewing and multipotent, and can be isolated from a variety of adult sources, but most commonly from bone marrow ASCs may provide cells for the reconstruction of bone tissue via osteogenic differentiation in in vivo-formed hydrogels. Although future studies will be needed to examine biomechanical characters for bone tissue engineered implants as the feature of osteogenic ASCs differentiation, we anticipate that ASCs used as described here will provide numerous benefits as a noninvasive treatment for debilitating orthopedic conditions. |
| 저자 |
장자용, 김문석, 이해방, 김다연, 권두연, 권진선, 손아름
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| 소속 |
아주대 |
| 키워드 |
Tissue Engineering; Adult Stem Cells; Osteogenic Differentiation
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| E-Mail |
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