| 초록 |
For the past decades, extensive research has been performed in the design of medical polymers for a variety of medical applications (Implants and devices, Drug delivery system, Tissue regeneration, etc). Great progress in these biomedical fields can be attributed to these scientific advances in medical polymers. Among them of interest is in situ forming hydrogels which have been widely utilized as therapeutic implants and therapeutic vehicles of drugs, proteins and cells for therapeutic applications, as they have several advantages based on minimally invasive injection procedure. In our group, various types of in situ forming hydrogels have been developed as injectable and sprayable bioactive matrices. The hydrogel matrices were made of various synthetic and natural polymers, including PEO-PPO copolymers and gelatin, keratin, hyaluronic acid, chitosan, and heparin. In this talk, it is introduced the strategies to use in situ forming hydrogels as advanced therapeutic matrices and therapeutic-delivering carriers (cells, growth factors, chemokines, proteins, peptides, H2O2, NO, etc) for therapeutic applications. Acknowledgement: This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIP)(NRF-2018R1A2B2004529), the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP(NRF-2015M3A9E2028578) and (MSIT) (No. 2018M3A9B5021319). |
