| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Controlled Co-releasing Behavior of Self-assembled Short Peptide Nanostructures |
| 초록 |
Carbon monoxide releasing molecules (CORMs) have become very popular mainly for their therapeutic applications in mammalian physiology. Meanwhile, short peptides have become attractive in the biomedical applications due to their easy synthesis process with simple molecular structure along with desired functionality which can be tuned depending on the consisting amino acids. Herein, we have developed CORM-attached self-assembling short peptides with varying hydrophilic (lysine) and hydrophobic (tryptophan) segments to understand the deep insight into the effect of their self-assembling behavior in CO-releasing properties. These peptides are subjected to take TEM, and cryo-EM images to observe the effect of hydrophilicity, and hydrophobicity in molecular packing, hence, in CO releasing properties. This work could enlighten the profound perception for the design of the CORM-peptide conjugates with customized bioactivity toward targeted organelle in the future. |
| 저자 |
Moumita Gupta, 김인혜, 김하연, 이은지
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| 소속 |
광주과학기술원 |
| 키워드 |
CO releasing molecule; Short peptide; Self-assembly
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| E-Mail |
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