| 초록 |
Despite of an enormous attention drawn to photo-responsive drug delivery systems, the most of current systems require complicated synthetic procedure. Herein we report a near-infrared responsive drug delivery carrier fabricated by simple mixing and extraction process without an incorporation of toxic materials. A mixture of anticancer drug (DOX) and 1-tetradecanol (PCM) are physically loaded into the mesoporous channel on silica-GO nanocomposite (GO@MS) to obtain phototheramally controllable drug releasing platform (DOX/PCM-GO@MS). An efficiency of the system based on IC50 against HeLa cell was 50 times more effective than that of free DOX driven by photothermal effect of GO core. In addition, a basal mechanism of an enhanced cytotoxicity was studied by flow cytometry. In conclusion, our results suggest a great potential for spatiotemporal control of photothermally triggered drug delivery system. |
