| 초록 |
In this study, hydrogel was fabricated using thiolated gelatin (GSH) and poly(ethylene glycol) diacrylate (PEGDA). Additionally, APS and TEMED were added as radical initiators. To make a hydrogel, GSH, PEGDA and initiator were prepared in PBS, respectively as follows concentrations: 2.5 % Gel-SH (LGSH), 5 % Gel-SH (HGSH), 12.5 % PEGDA (LPEGDA), 25 % PEGDA (HPEGDA), 4 % APS and 2 % TEMED initiator (HInitiator), and 3 % APS and 1.5 % TEMED initiator (LInitiator). The hydrogel were prepared in 6 different groups; (1) HGSH-LPEGDA-LInitiator, (2) HGSH-LPEGDA-HInitiator, (3) LGSH-HPEGDA-LInitiator, (4) LGSH-HPEGDA-HInitiator, (5) HGSH-HPEGDA-HInitiator, and (6) HGSH-HPEGDA-LInitiator. Herein, the characteristics including porous structures, hydrolytic degradation properties (i.e., swelling ratio, sol fraction, and mass remaining), mechanical property (i.e., young’s modulus), embedded BSA release kinetics, and cytocompatibility of hydrogels were investigated. |
