| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Cancer therapy using glucose-sensitive polymeric nanoparticles |
| 초록 |
Cancer is a leading cause of morbidity and mortality in the world. Functionalized polymeric nanoparticles have been considered promising as nanomedicine for the treatment of many diseases, including cancer, as they can be biomimetically designed to recognize cellular and molecular processes in the body. In this study, we hypothesized that phenylboronic acid-conjugated glycol chitosan could form polymeric micelles and the self-assembled nanoparticles could induce glucose deprivation in the tumor cells due to inhibition of glycolysis metabolism. These derivatives formed self-assembled nanoparticles and their structure was varied in response to changes in the glucose concentration. The cellular uptake of glucose-sensitive nanoparticles induced glucose deprivation of the cells, resulting in the decrease of tumor size and mass in a tumor-bearing mice model. This approach to developing functionalized polymeric nanoparticles may be useful for of the treatment of various cancers. |
| 저자 |
이장욱1, 민현수2, 유동길2, 김광명2, 권익찬2, 이근용1
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| 소속 |
1한양대, 2한국과학기술(연) |
| 키워드 |
cancer therapy; functionalized polymeric nanoparticles; anti-glycolysis; glucose deprivation; phenylboronic acid; glycol chitosan
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| E-Mail |
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