| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
콜로이드,계면화학 |
| 제목 |
The formation of biodegradable vesicles from Poly(2-hydroxyethyl aspartamide) grafted with lactic acid oligomers in aqueous solution |
| 초록 |
Amphiphilic copolymer, poly(2-hydroxyethyl aspartamide) (PHEA) grafted with lactic acid oligomers (LAs) with various degree of substitution (DS) was successfully synthesized by the formation of amide linkage between PHEA and LA. The self-aggregates of PHEA-g-LA in dilute aqueous solution were prepared by precipitate-dialysis method and characterizd. With the light scattering measurement results and TEM images we could confirm the formation of polymer vesicles from copolymers with high DS. The structure of polymer aggregates were changed from micelle to vesicle with increased DS, which means increased hydrophobicity leads the structural transition. We also prepared micron-sized giant vesicles by using film-hydration method and visualized with confocal laser scanning microscopy (CLSM). |
| 저자 |
이현진1, 양승림2, 김종득1
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| 소속 |
1한국과학기술원, 2LG 화학 기술(연) |
| 키워드 |
PHEA; Lactic acid oligomer; polymer vesicle
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| E-Mail |
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