| 초록 |
There is a rapidly increasing interest in developing chemiluminescence resonance energy transfer-based nanoparticles (CRET-NPs) for diagnosis and treatment of cancer. By enabling the high specific imaging at the sites of interest, it is possible to increase the therapeutic efficacy of photodynamic therapy (PDT). However, the translational barriers to conventional CRET-NPs for PDT are limited in low quantum yield of photosensitizer and short duration of chemiluminescence signal. To overcome these limitations, we investigated a new concept of CRET-NPs, capable of enhancing the photoacoustic (PA) and reactive oxygen species (ROS) quantum yields, simultaneously. At the tumor sites, the CRET-NPs was designed to amplifying the PA signal via thermal expansion induced vaporization. Besides, CRET-NPs significantly increased the ROS quantum yield through electron transfer and self-illumination. Overall, CRET-NPs might hold great translational potential as phototheranostic agents. |
