| 초록 |
Reactive Oxygen Species (ROS) have been caused to many diseases, aging, obesity in human body. To solve these obstacles, antioxidant agent as natural material has been used for ROS elimination. However, it has a problem such as very a low bioavailability in body and high toxicity. To overcome these problems, we prepared to antioxidant agent-encapsulated chitosan microsphere (AECM) by using spray dry method. Its structural analysis of AECM was confirmed by 1H-NMR. Also, The encapsulation efficiency of antioxidant agent from AECM was analyzed by UV-Vis spectrophotometer. Additionally, morphological property of AECM was observed by SEM, which had a spherical shape and particle size of 2 ~ 5 ㎛. In addition, its cytotoxicity was evaluated by MTT assay. These results suggest that AECM can apply as antioxidant agent with low toxicity and improved bioavailability. |
