| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Biocompatible Redox-Responsive Photosensitizer-Nanogel Complexes to Elucidate Intracellular Mechanisms of Photodynamic Therapy |
| 초록 |
Photodynamic therapy(PDT) have attracted to be a non-invasive cancer therapy in that generation of toxic reactive oxygen species(ROS) is spatiotemporally controllable. However, using conventional photosensitizers have limitations due to their high light-dose requirement and inherent cytotoxicity even in dark condition. Herein, we present a photosensitizer-nanogel complexes, which induces apoptosis of cancer cells by responding to the highly reductive cancer environment and ROS-mediated oxidative stress with low light intensities. Redox-responsive nanogels were synthesized from hyperbranched polyether containing disulfide bonds, and the nanogels encapsulating iridium photosensitizers(IrNG) show enhancement in photo-sensitive cytotoxicity, which can reduce the side effects like uncontrolled cell death in dark condition. To explain this result, we will discuss the ROS-mediated crosslinked proteins and redox-sensitive protein expression levels which can lead cancer cells to apoptosis. |
| 저자 |
이채규1, 이채헌1, 이준희1, 김병수2, 권태혁1
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| 소속 |
1울산과학기술원, 2연세대 |
| 키워드 |
Photodynamic therapy; Drug delivery system; Iridium complex; Nanogel; Disulfide-thiol exchange; redox-responsive degradation; apoptosis; cancer
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| E-Mail |
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