| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Peptidomimetic Antimicrobial PEGtides:A Modular Approach to Combat Bacteria |
| 초록 |
Despite their high potency, the widespread implementation and use of antimicrobial peptides is still challenging due to their low in vivo efficacy and productivity, and high hemolytic activity. Herein, we address these issues by employing a minimal approach to mimic the key amino acid residues present in antimicrobial peptides, such as lysine, leucine, and serine, on the highly biocompatible poly(ethylene glycol) (PEG) as a platform. We introduce a series of PEG-based peptides (PEGtides) using functional epoxide monomers, corresponding to each key amino acid. These PEGtides possessed highly potent bactericidal activities as well as controlled selectivity with respect to their hemolytic behavior. The critical role of the PEGtide microstructure in the selectivity was also thoroughly analyzed using coarse-grained molecular dynamic simulations. This modular approach shed a light on the design principles necessary for the further and future development of antimicrobial polymers. |
| 저자 |
김민성1, 문원식1, 정우혁2, 이준희1, 조가영1, 권지수1, 안동준2, Robert J. Mitchell1, 김병수3
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| 소속 |
1울산과학기술원, 2고려대, 3연세대 |
| 키워드 |
Antimicrobial polymer; Simulation; Ring-opening polymerization
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| E-Mail |
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