| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Effect of Drug Loading in Chitosan/PCL Microsphere on fibroblast growth |
| 초록 |
The efficacy of medical drugs can be strongly affected by the types of drug delivery system. At the same time, drug release from carrier is directly related by the formulation of the drug-loaded carrier. In drug delivery system, organic microspheres are often adopted as drug carrier. Chitosan (CHN) possesses highly positive charges, which can be utilized to immobilize organic drugs via electrostatic interaction and used in medical and pharmaceutical applications. poly(e-caprolactone) (PCL) is biocompatible and degrades under physiological environment. In this study, we prepared microspheres by combining chitosan CHN and PCL. The morphology, surface charge, and chemical state of the comlex microspheres were analyzed using SEM, zeta potential, and FTIR. We also analyzed the drug release kinetics using high perfromance liquid chromatography. Fibroblast proliferation in response to drug release was evaluated. |
| 저자 |
마진쉬엔, 엄혜원, 류규환, 김경현, 이재영, 서아인, 최선희, 이우걸
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| 소속 |
단국대 |
| 키워드 |
Chitosan; PCL; Microsphere; Drug Delivery
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| E-Mail |
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