| 초록 |
Controlled drug delivery is important for therapeutic efficacy. Among stimuli-responsive polymers, thermo-responsive polymers have drawn much attention because this stimulus occur in the body and can be given from outside, which makes it easier to control. Here, we introduce Poly(N-vinyl caprolactam)(PVCL) microparticles for controlled drug delivery. Unlike PNIPAm, PVCL has good biocompatibility. Microparticles were synthesized via Stop Flow Lithography technique. We verified that polymer network in microparticles are contracted above certain temperature known as lower critical solution temperature(LCST). After adjusting the LCST to body temperature by adding poly ethylene glycol 700 diacrylate as a hydrophilic component, we conducted drug release using Doxorubicin and revealed that the releasing rates were significantly higher at above LCST than below LCST. Moreover, we fabricated gold nanorod(GNR) incorporated PVCL microparticles to control drug release by exposure of near-infrared. |
