| 초록 |
Computed Tomography (CT) is a widely used imaging technique for ischemic stroke due to its short operation time. While conventional molecular CT contrast agents such as Iopamidol can locate the blocked blood vessel, the information about exact size and shape of the clot cannot be gained. Several nanoparticle-based contrast agents such as gold nanoparticle have shown the size and shape, still toxicity of accumulated nanoparticles is unrevealed. Therefore, we suggest a biodegradable polymeric nanoparticle as CT contrast agents. Condensation polymerization was done using a water-soluble iodinated monomer and a biodegradable linker. Degradation of polymeric nanoparticle was available in PBS and degradation products were water soluble. CT Imaging was successful compared to molecular CT contrast agents. In conclusion, we expect the polymeric nanoparticles work as biodegradable CT contrast agents capable of imaging the clot with exact size and shape. |
