| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Ultra-Sensitive Amyloid-β Sensor with Gold nanoparticles and Conducting polymers Composite Electrode for Early Diagnosis of Alzheimer’s Disease |
| 초록 |
In this work, an electrochemical sensor was prepared using gold nanoparticles-poly (3,4-ethylenedioxythiophene-poly(thiophene acetic acid) [AuNPs-PEDOT-PTAA] to immobilize cellular prion protein (PrPC) for the detection of amyloid beta oligomer (AβO). AuNPs and PEDOT composite electrode induced a high conductivity and then, provided the high sensitivity to AβO sensing. PEDOT was enhanced the electrical conductivity and the adhesion between PTAA and the composite electrode. The thiol and carboxyl groups of PTAA were played the linking agent between the composite electrode and the amine-terminated PrPC peptide. The impedance response of the optimized AuNPs-PEDOT-PTAA biosensor showed a proportional relationship with the concentrations of AβO in the range from 10-2 fM to 102 mM. The sensitivity at a femtomolar level and high selectivity to the AβO can be used in practical for the early diagnosis of Alzheimer’s disease. |
| 저자 |
JIELING QIN, 조미숙, 이영관
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| 소속 |
성균관대 |
| 키워드 |
cellular prion protein; gold nanoparticles; conducting polymer; amyloid beta oligomer; Alzheimer's disease
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| E-Mail |
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