| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Antibiotic-Loaded Alginate Hydrogel with Sustained Release for the Treatment of Otitis Media |
| 초록 |
Otitis media is defined as an inflammatory disease occurring to middle ear. Common otitis media therapies are oral and injection administrations of antibiotics. However, those therapies have a possibility of systemic toxicity, various side effects, and low antibacterial effects. In this study, we prepared an injectable antibiotic (ofloxacin)-loaded alginate hydrogels with sustained release of the drug, which can be a desirable system for the treatment of otitis media. The drug was incorporated in the alginate hydrogel using alginate/CaSO4 mixture with controllable gelation rate. In vitro the drug release behavior, cytotoxicity, and antibacterial effect of an antibiotic-loaded hydrogel were investigated. It was observed that the ofloxacin loaded in the hydrogel show sustained release behavior for up to 14 days. The ofloxacin-loaded hydrogel showed high cell viability compared to the free drug. The ofloxacin-loaded hydrogel also showed highly effective antibacterial effect. |
| 저자 |
이혜리1, 김태호1, 김용태1, 이인수1, 오세행2, 이진호1
|
| 소속 |
1한남대, 2단국대 |
| 키워드 |
Alginate Hydrogel; Antibiotic; Sustain Release; Otitis Media
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| E-Mail |
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