| 초록 |
The emergence and spread of infectious pathogens is a major threat to the community and global health. Moreover, the overuse of antibiotics with broad spectrum has given rise to superbugs, which results in limited options for treating the infections. To solve this problem, we first need a facile method to rapidly diagnose the infection with high sensitivity and specificity, and secondly a specific treatment strategy that can target different types of pathogens selectively. We have investigated various molecular labeling approaches using multifunctional nanomaterials and rapid linking chemistries, for rapid and sensitive detection of bacterial pathogens. Various molecular ligands such as small molecule antibiotics or oligonucleotide probes were used to detect different types of multidrug-resistant bacteria. Furthermore, we also developed a target-specific treatment strategy for the infections, based on nonviral delivery of a polymer-derivatized genome editing nanocomplex. |
