| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Hyaluronic Acid Hydrogels for Tissue Augmentation Applications |
| 초록 |
Degradation controlled hyaluronic acid (HA) hydrogels were successfully developed for tissue augmentation applications. HA has a different conformational structure in water and in organic solvent, and the carboxyl group of HA is known to be the recognition site of hyaluronidase and HA receptors. Based on these findings, HA was chemically modified by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA in water to prepare HA-ADH and in the mixed solvent of water and ethanol to prepare degradation controlled HA-ADH. Three kinds of HA hydrogels were prepared by the crosslinking of HA-ADH or degradation controlled HA-ADH with bis(sulfosuccinimidyl) suberate (BS3), and by the crosslinking of HA-OH with divinyl sulfone (DVS). In vitro and in vivo degradation tests showed that HA-DVS hydrogels were degraded the most rapidly, followed by HA-ADH hydrogels and degradation controlled HA-ADH hydrogels. There was no adverse effect during and after the in vivo degradation tests. |
| 저자 |
공지현1, 오은주1, 강선웅2, 김병수2, 한세광1
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| 소속 |
1포항공과대, 2한양대 |
| 키워드 |
Hyaluronic acid; Hydrogels; Hyaluronidase; Degradation; Biocompatibility
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| E-Mail |
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