| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Preparation and properties of porous alginate-based hydrogels from click reaction between alginate-norbornene and disulfide-tetrazine crosslinkers |
| 초록 |
The current study aimed to report the effect of hydrogel porosity, which may be controlled by the design of crosslinkers, on drug release behavior. Porous alginate-based hydrogels were prepared from the inverse electron demand Diels-Alder reaction of alginate-norbornene (Alg-Nb) and disulfide-tetrazine (S-Tz). The porosity of hydrogels could be controlled by adjusting the amount of S-Tz crosslinker. Gel formation was facilitated by a “click” reaction between Nb and Tz, which produced nitrogen gas, which in turn, acted as an in-situ pore generator. Proportion of crosslinker and porosity were concluded to be significant factors for drug release behavior of hydrogels. |
| 저자 |
박한솔, Sonita Afrita Purba Siboro, 이시윤, 임권택
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| 소속 |
부경대 |
| 키워드 |
alginate; hydrogels; disulfide crosslinkers; drug release; porosity
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| E-Mail |
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