| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 | 21권 1호 |
| 발표분야 | 생체재료 |
| 제목 | Acidic pH-responsive, doxorubicin loading polymeric photosensitizer nanoparticles for cancer therapy |
| 초록 | Nanoparticles(NP) is one of the great method to treat cancer. However, this method has limitation such as reduced intracellular delivery and endosomal capture. Thus, cancer therapy using NP requires to effective intracellular delivery and endosomal escaping. Photosensitizer(PS) is as one of the attractive agent for cancer therapies. PS generate cytotoxic reactive oxygen species(ROS), when irradiated with specific wavelengths. photochemical internalization (PCI) can effective endosomal escaping because generated ROS enable to a PCI. We have designed pH-sensitive biopolymer(pB) conjugated PS nanoparticles loaded doxorubicin(DOX@PS-pB). DOX@PS-pB can effective intracellular delivery Because pH-responsive moieties of pB protonation in acidic environment. In addition, PCI by PS can endosomal escaping and cancer can be treated by the release of DOX. |
| 저자 | 강다운, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | pH-responsive; photosensitizer; drug delivery |
