| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Development of Lipid Coated-Poly (lactic-co-glycolic acid) Nanoparticles for Enhanced Chemotherapeutic Efficiency |
| 초록 |
Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable polymer and show potential as drug delivery systems for both hydrophobic and hydrophilic drugs. However, PLGA nanoparticles demonstrate rapid recognition by the mononuclear phagocyte program (MPS) and blood clearance during circulation. Here, we propose a one-layer lipid-coated PLGA nanoparticle (PLGA lipid NPs) to increase the stability of nanoparticles by preventing the opsonization effect and enhance the drug delivery efficiency for chemotherapy. The result showed the increase of stability and intracellular uptake efficiency of PLGA lipid NPs. Also, the biodistribution results and tissue penetration efficiency of PLGA lipid NPs were higher than that of PLGA NPs. These findings suggest that the PLGA lipid NPs could be suitable platform for drug delivery due to in vitro and in vivo efficiencies. |
| 저자 |
김도연, 김현철
|
| 소속 |
서강대 |
| 키워드 |
polymeric nanoparticles; drug delivery; chemotherapy
|
| E-Mail |
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