| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The influence of molecular weight to Transdermal Drug Delivery System using Microneedle |
| 초록 |
Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules. The present study was designed to develop the microneedle type transdermal drug delivery system using OVA, Insulin and Bufexamac as model drug. The in vitro study of Hairless mouse skin permeability for drug was carried out at PBS, 37 ℃ for 12 hour with a modified Franz's diffusion cell after the skin treatment by microneedle system. The drug release was determined by Fluorescein Spectrophotometer and compared at molecular weights of each drug. Microneedle-treated skin exhibited the maximum 20 times higher release amount of drug more than a control. Generally, transdermal delivery system using microneedle seems that drug is more permeable as molecular weight is lower. Acknowledgment : This work was supported by KMOCIE(10016551) |
| 저자 |
이창래1, 서성미2, 엄성용3, 이한구3, 김문석4, 이해방4, 이종문1, 강길선1
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| 소속 |
1전북대, 2부경대, 3디에스엔지, 4한국화학(연) |
| 키워드 |
microneedle; molecular weight; transdermal
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| E-Mail |
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