초록 |
In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking technique was used to prepare sodium alginate/ poly(vinyl alcohol)/betonite beads. Beads of different compositions were prepared by varying the amount of poly(vinyl alcohol) and bentonite and characterizing it by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction(XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. |